Amgen's AMGN Shares Soar on $1.44 Billion Volume Spike, Rank 78th in U.S. Equity Trading

On October 1, 2025, Amgen (AMGN) surged 5.78% as trading volume reached $1.44 billion, a 45.82% increase from the prior day, ranking the stock 78th in volume among U.S. equities. The biotech giant's performance reflected investor focus on its therapeutic pipeline advancements and regulatory developments.

Recent regulatory updates for Amgen’s biosimilar portfolio highlighted potential market expansion opportunities. Analysts noted that favorable patent litigation outcomes in late September bolstered investor confidence, reducing near-term competition risks for key oncology and hematology products. The company’s Q3 earnings call emphasized sustained demand for Kyprolis and Blincyto, with no material supply chain disruptions reported.

Strategic partnerships remain a focal point for Amgen’s growth trajectory. A newly announced collaboration with a European academic institution for gene therapy research was cited as a catalyst for long-term innovation. Market participants also observed increased short-covering activity, with positioning data indicating a 12% reduction in net short interest since mid-September.

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