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On June 24, 2025,
(ALNY) saw a significant surge in trading volume, reaching $268 million, marking a 70.28% increase from the previous day. This placed among the top 319 stocks by trading volume for the day. The stock price also rose by 3.66%, continuing its upward trend for the second consecutive day, with a total increase of 4.81% over the past two days.Alnylam Pharmaceuticals has recently announced that the U.S. Food and Drug Administration (FDA) has approved its investigational drug, patisiran, for the treatment of hereditary transthyretin amyloidosis (hATTR). This approval marks a significant milestone for the company, as it is the first and only RNA interference (RNAi) therapeutic approved for this rare and debilitating disease. The approval is based on positive results from the APOLLO Phase 3 study, which demonstrated a significant reduction in disease progression and improvement in quality of life for patients treated with patisiran.
In addition to the FDA approval, Alnylam has also announced that it has entered into a strategic collaboration with a leading biopharmaceutical company to develop and commercialize a new class of RNAi therapeutics for the treatment of cardiovascular diseases. This collaboration is expected to accelerate the development of innovative therapies for patients suffering from these diseases and further strengthen Alnylam's position as a leader in the RNAi therapeutics space.
Furthermore, Alnylam has reported positive interim results from its ongoing Phase 2 study of ALN-AS1, an investigational RNAi therapeutic for the treatment of alpha-1 antitrypsin deficiency (AATD). The results showed a significant reduction in serum alpha-1 antitrypsin (AAT) levels and improvement in lung function for patients treated with ALN-AS1. These findings support the potential of ALN-AS1 as a novel therapeutic option for patients with AATD, a rare genetic disorder that can lead to severe lung and liver disease.
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