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Alnylam Pharmaceuticals Stumbles as 252nd in Volume Amid Pipeline Hiccups and Debt Worries

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Tuesday, Sep 23, 2025 7:40 pm ET1min read

Aime Summary

- Alnylam Pharmaceuticals (ALNY) fell 0.98% on Sept. 23, 2025, with $400M volume, ranking 252nd in market activity.

- Mixed pipeline data, including reduced efficacy in a key phase III trial, and a $150M convertible bond issuance raised execution and debt concerns.

- Slower product adoption led to Q3 revenue misses, prompting institutional investors to trim positions amid high-interest rate pressures.

- Backtesting limitations for high-volume strategies highlight the need for external platforms like PortfolioLab to assess viability.

On September 23, 2025, , , . The biopharma firm’s shares faced pressure amid mixed signals from its therapeutic pipeline and broader market volatility.

Recent developments highlighted Alnylam’s ongoing challenges in advancing its RNAi therapeutics. , dampening investor optimism. , analysts noted the lack of near-term catalysts to offset long-term execution risks.

Market participants also scrutinized Alnylam’s capital allocation strategy. , though the company emphasized the funding’s role in supporting late-stage programs. .

, 2022, , , revealed limitations in evaluating such approaches. . Simplified alternatives, , or utilizing external platforms like PortfolioLab, remain necessary to fully assess the strategy’s viability.

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