Alnylam Pharmaceuticals (ALNY) Shares Drop 0.71% as Daily Trading Volume Falls to 287th Rank
On September 26, 2025, Alnylam PharmaceuticalsALNY-- (ALNY) reported a 0.71% decline in its stock price amid a trading volume of $360 million, ranking 287th in daily market activity. The biopharmaceutical company’s shares experienced muted investor interest despite ongoing focus on its pipeline of RNA interference therapies targeting genetic disorders.
The recent performance reflects broader market dynamics rather than new product developments or regulatory updates. Analysts noted that Alnylam’s stock remains sensitive to clinical trial progress and partnership announcements, though no material news was reported during the period. The volume suggests limited short-term catalysts influencing trading patterns.
To back-test a strategy of purchasing the top 500 U.S.-listed stocks by daily trading volume and holding for one day, several parameters must be defined. The universe should include only common stocks, with the top-500 list recalculated daily. Entry and exit conventions, position sizing, and friction costs (e.g., transaction fees) require clarification to ensure technical feasibility. Constructing a synthetic equal-weight index from volume data is the most accurate approach but demands extensive data aggregation, while using a proxy like SPY simplifies execution at the cost of precision.

Hunt down the stocks with explosive trading volume.
Latest Articles
Stay ahead of the market.
Get curated U.S. market news, insights and key dates delivered to your inbox.

Comments
No comments yet