Alligator's Strategic Pivot: Focusing on Mitazalimab Amid Cost-Cutting Measures

Alligator Bioscience, a biotech company specializing in immuno-oncology, has announced a strategic shift to concentrate resources on its lead asset, mitazalimab, while implementing a cost reduction program. This move aims to maximize long-term value creation and solidify Alligator's position in the competitive biotech landscape.

The company's decision to focus on mitazalimab is based on its promising Phase 2 clinical trial results, which demonstrated unprecedented survival benefits in first-line metastatic pancreatic cancer. Alligator believes that mitazalimab should advance into Phase 3 development as soon as possible, given its potential to revolutionize cancer treatment.



To fund this strategic pivot and ensure financial sustainability, Alligator plans to reduce its workforce by approximately 70%, primarily within discovery and non-clinical units. This restructuring is expected to result in annual cash savings of at least SEK 65 million, strengthening the company's ability to continue developing mitazalimab and enhancing its attractiveness for partnerships.

Simultaneously, Alligator has announced plans for a Rights issue to be completed in Q1 2025. If fully subscribed, this financing initiative will secure funding up until the end of 2025, further bolstering the company's financial position.



Alligator is confident that its strategic focus on mitazalimab, combined with cost-cutting measures, will lead to outstanding returns for shareholders. The company expects to report 24-month follow-up data from the mitazalimab OPTIMIZE-1 Phase 2 trial in Q1 2025, which could set mitazalimab apart from other treatments in metastatic pancreatic cancer and pave the way for regulatory approval and commercialization.

While the restructuring may impact Alligator's ability to innovate and attract top talent in the future, the company's commitment to continuing limited research activities, primarily related to mitazalimab, through internal and external resources may help mitigate these risks. Alligator's success will depend on how effectively it supports affected employees and communicates its vision for the future.

In conclusion, Alligator Bioscience's strategic pivot towards mitazalimab, coupled with cost reduction measures, positions the company to capitalize on the potential of its lead asset and maximize long-term value creation. The success of this approach will be crucial for Alligator to maintain and grow its market position in the competitive biotech landscape.