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AIM ImmunoTech (AIM) Q2 Earnings call transcript Aug 16, 2024

AInvestFriday, Aug 16, 2024 9:07 pm ET
2min read

In the latest earnings call, AIM ImmunoTech, a biotech company focused on developing innovative treatments for various diseases, provided updates on its clinical advancements and financial health. The call, led by CEO Thomas Equels and Scientific Officer Christopher McAleer, showcased the company's ongoing efforts in the field of immunology and its commitment to advancing Ampligen, its key therapeutic candidate, across multiple development programs.

Ampligen's Potential in Oncology

One of the highlights of the call was the discussion on Ampligen's potential in oncology. According to Dr. McAleer, recent preclinical data showed that Ampligen, when combined with dendritic cell vaccines, including anti-PD-1, PD-L1 checkpoint inhibitors, slowed tumor growth with improved survival in a preclinical model. This data, published in the prestigious peer-reviewed journal Vaccines, has given the company confidence in advancing its ongoing clinical oncology programs in pancreatic and ovarian cancer.

Clinical Progress in Pancreatic Cancer

In the realm of pancreatic cancer, AIM ImmunoTech is conducting a Phase I/II trial (DURIPANC) to determine the safety and efficacy of combining Ampligen with AstraZeneca's durvalumab. The first cohort of the dose escalation has completed safety evaluation, and the second cohort is underway. Dr. McAleer expressed optimism about the potential of Ampligen in this complex disease, noting that the initial data from patients at the lowest dose level showed similar stable disease time to the median progression-free survival seen with Ampligen alone.

Ongoing Research in Ovarian Cancer

In ovarian cancer, AIM ImmunoTech is working on a trial combining Ampligen with pembrolizumab and cisplatin in platinum-sensitive ovarian cancer. Preliminary results, as shared by Dr. Robert Edwards at the University of Pittsburgh, have been promising, with a clinical benefit rate of greater than 60% and significant immune changes to the tumor microenvironment. AIM ImmunoTech is eagerly awaiting follow-up data on the duration of response, as the immune modulating properties of the treatment could help address the high recurrence rate in ovarian cancer patients.

Financial Health and Future Prospects

CEO Thomas Equels highlighted the company's financial stability, with a cash position sufficient to fund operations through key milestones. Research and development expenses have been managed carefully, and the company has collaborated with big pharma companies like AstraZeneca and Merck on clinical studies. AIM ImmunoTech's commitment to transparency, as demonstrated through its CEO corner program, has been appreciated by stakeholders.

Conclusion

AIM ImmunoTech's Q2 2024 update underscores the company's dedication to advancing Ampligen in the field of oncology. With promising preclinical and early clinical data, the company is well-positioned to continue its research and development efforts, particularly in the areas of pancreatic and ovarian cancer. The company's financial stability and strategic collaborations bode well for its future prospects, underscoring its potential to unlock value for all stakeholders. As the company continues its journey, it remains focused on its mission to improve patient lives through immunology.

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