Aethlon Medical's 97.3% Stock Surge Drives $300M Volume Spree and 296th Trading Activity Rank

Aethlon Medical (AEMD) surged 97.30% on August 21, 2025, with a trading volume of $0.30 billion—marking a 3,348.22% increase from the previous day. The stock ranked 296th in trading activity for the day, signaling heightened short-term interest among investors.

The exceptional volume spike suggests a potential shift in market sentiment toward the company, possibly driven by unconfirmed catalysts such as regulatory updates or strategic partnerships. Analysts note that while the surge aligns with typical patterns for biotech stocks, the magnitude of the volume increase warrants closer scrutiny for liquidity risks and overvaluation concerns.

A strategy leveraging high-volume stocks has historically shown moderate returns, with a compound annual growth rate (CAGR) of 6.98% from 2022 to 2025. However, the approach experienced a maximum drawdown of 15.59% during the backtest period, particularly in mid-2023. This underscores the need for diversified risk management even in strategies that appear stable over time.