Acurx Surges 88.81% on $220M Volume Climbs to 496th in Trading Activity

On October 8, 2025, Acurx (ACXP) surged 88.81% with a trading volume of $220 million, marking a 426.49% increase from the previous day’s volume. The stock ranked 496th in trading activity among listed equities, indicating heightened investor engagement following recent developments.

Recent market activity reflects strategic positioning in oncology and infectious disease therapies, with Acurx’s pipeline demonstrating potential for near-term regulatory milestones. Analysts note that the company’s focus on high-impact therapeutic areas has attracted renewed institutional attention, particularly as clinical trial data aligns with key market expectations. However, the rapid price movement suggests speculative positioning amid limited public guidance on long-term capital allocation.

To run this back-test accurately I need to confirm a few practical details: 1. Universe • Which market do you want to scan for “top 500” stocks — U.S. listed equities (NYSE + NASDAQ), a specific country, or a global universe? • If the universe sometimes contains fewer than 500 actively traded names, should we simply take all that are available that day? 2. Weighting & capital allocation • Do you want the 500 names equally-weighted each day (i.e., 0.2 % of capital per position)? • Any transaction-cost assumption, or can we ignore fees/slippage? 3. Benchmark (optional) • Would you like the results compared against a benchmark such as SPY or an equal-weight universe? Once these points are set I can generate the entry/exit signals and run the 2022-to-present back-test for you.