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Aardvark Therapeutics announced new preclinical data for ARD-201, a potential treatment for obesity and metabolic diseases. In a gold-standard model, ARD-201 resulted in a 19% body weight reduction after 30 days of treatment. The drug also attenuated weight regain after discontinuing GLP-1RA therapy and improved weight loss when combined with tirzepatide. Aardvark plans two Phase 2 clinical trials, focusing on weight rebound and weight loss as a monotherapy and in combination with GLP-1RA.

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