a16z Promotes Wuollet to Steer Crypto's Regulatory and Innovation Strategy

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Monday, Nov 10, 2025 11:00 pm ET2min read
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- Andreessen Horowitz promoted Guy Wuollet to crypto general partner, focusing on infrastructure, DeFi, and DePIN to drive blockchain innovation.

- U.S. regulatory clarity on crypto ETP staking and CFTC discussions on domestic spot trading align with a16z's advocacy for market-friendly policies.

- The firm's investments in projects like Pakistan's ZAR stablecoin and stakes in Solana/EigenLayer highlight its strategy to bridge traditional and decentralized finance.

- Wuollet's track record of 20+ crypto investments positions a16z to navigate market volatility while advancing tokenized collateral and cross-chain solutions.

Andreessen Horowitz's (a16z) crypto division has promoted Guy Wuollet to General Partner, a move that cements his role in shaping the firm's investment strategy as the digital asset sector continues to evolve under regulatory and market shifts. Wuollet, who joined a16z in 2020 after interning during his studies at Stanford University, now becomes the fourth general partner in the division

. His focus areas—infrastructure, decentralized finance (DeFi), and decentralized physical infrastructure networks (DePIN)—align with a16z's broader push to capitalize on blockchain innovation.

The promotion comes as a16z and other major crypto firms navigate a regulatory landscape marked by recent U.S. policy developments. Last month, the Treasury Department and IRS issued guidance allowing crypto exchange-traded products (ETPs) to stake assets and distribute rewards to investors, a move hailed by industry leaders including a16z and Paradigm as a "huge win" for innovation

. This clarity has enabled regulated funds to integrate staking into their offerings, a key step toward mainstream adoption.

Simultaneously, a16z has been vocal in advocating for U.S. regulatory frameworks that support crypto markets. In a recent comment letter to the Commodity Futures Trading Commission (CFTC), the firm emphasized the importance of launching leveraged spot crypto products on domestic exchanges to curb offshoring of retail trading

. The CFTC, led by Acting Chair Caroline Pham, is reportedly in talks with exchanges like CME and Coinbase Derivatives to introduce such products as early as next month.

a16z's influence extends beyond regulatory advocacy. The firm has also made strategic investments to bolster infrastructure and accessibility in the crypto space. For instance, it recently backed ZAR, a Pakistan-based fintech startup aiming to expand stablecoin access to the country's unbanked population

. This aligns with a16z's broader strategy to support projects that bridge traditional finance and decentralized systems.

Wuollet's promotion reflects a16z's commitment to fostering talent and leadership within the crypto ecosystem. With over 20 investments under his belt—including stakes in

, , and Morpho—the new general partner is poised to drive further innovation in areas like tokenized collateral and cross-chain interoperability. His role will be critical as the firm navigates a market still grappling with volatility, as seen in recent price swings and whale accumulation patterns.

As the crypto industry matures, a16z's dual focus on regulatory engagement and venture capital positions it to shape the next phase of digital asset adoption. With Wuollet's expertise and the firm's growing portfolio, the division is well-placed to address both technical and policy challenges in the sector.