a16z Promotes Wuollet to Lead Crypto's Regulatory and Institutional Integration

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Monday, Nov 10, 2025 10:41 pm ET2min read
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- a16z crypto promotes Guy Wuollet to General Partner, emphasizing its commitment to expanding crypto infrastructure and regulatory engagement.

- U.S. Treasury and IRS guidance allows crypto ETPs to stake assets and distribute rewards, aligning with a16z's push for crypto-traditional finance integration.

- The firm supports institutional-grade products like Bitwise 10 Crypto Index Fund and advocates for $25B leveraged spot crypto trading opportunities via CFTC initiatives.

- Cross-border efforts include Pakistan's ZAR stablecoin funding and Zenrock's privacy-preserving DeFi projects, reflecting a16z's focus on interoperability and adoption.

- With regulatory shifts in the U.S., a16z positions itself to capitalize on institutional crypto markets, protocol innovation, and global financial inclusion through strategic investments.

a16z crypto, the venture capital arm of Andreessen Horowitz, has promoted Guy Wuollet to General Partner, a move underscoring its deepening commitment to scaling crypto infrastructure and regulatory engagement. Wuollet, who previously served as a Partner, has been instrumental in shaping the firm's investments in blockchain protocols, DeFi, and institutional-grade crypto products. His promotion comes amid a pivotal year for U.S. crypto policy, with a16z actively influencing regulatory clarity and market structure

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The U.S. Treasury and IRS recently issued guidance permitting crypto exchange-traded products (ETPs) to stake digital assets and distribute rewards to investors, a development a16z hailed as a "huge win" for innovation

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This aligns with a16z's broader strategy to integrate crypto into traditional finance, as seen in its backing of regulated products like the Bitwise 10 Crypto Index Fund, which holds and as core assets. The firm's advocacy extends to leveraged trading, with the Commodity Futures Trading Commission (CFTC) now exploring spot crypto trading on regulated exchanges-a potential $25 billion market opportunity.

a16z's influence also extends to cross-border initiatives. In Pakistan, the firm co-led a $12.9 million funding round for ZAR, a fintech startup aiming to expand stablecoin access to the country's 100 million unbanked adults

. Meanwhile, a16z's portfolio company Zenrock launched zenZEC, a wrapped token enabling privacy-preserving DeFi on Solana-a project reflecting the firm's focus on interoperability and institutional adoption.

The promotion of Wuollet highlights a16z's dual focus on technical innovation and regulatory navigation. As the CFTC's Caroline Pham prepares to exit for a role at MoonPay, a16z's opposition to certain regulatory nominees-such as Brian Quintenz-signals its active role in shaping the crypto policy landscape

. This aligns with the firm's investments in projects like Mutuum Finance, a DeFi lending platform that has raised $18.6 million in its presale, and its advocacy for structured crypto products like SovFi's tokenized sovereign debt instruments.

With the U.S. regulatory environment evolving rapidly, a16z's promotion of Wuollet positions the firm to capitalize on emerging opportunities in institutional-grade crypto products, cross-border finance, and protocol-level innovation. As Pham notes, leveraging existing authorities to bring crypto markets under U.S. oversight could attract $25 billion in institutional capital-a target a16z is well-positioned to facilitate

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