Zoetis Shares Fall 1.78% as $390M Volume Ranks 289th in Market Activity

Zoetis (ZTS) closed 1.78% lower on October 7, 2025, with a trading volume of $0.39 billion, ranking 289th in market activity. The decline follows mixed industry sentiment and broader market volatility. Analysts note that the stock’s performance remains sensitive to macroeconomic signals and sector-specific dynamics.

Recent developments in veterinary pharmaceuticals and animal health markets have shown limited directional clarity. While demand for livestock-related products remains stable, regulatory uncertainties and competitive pressures continue to weigh on investor confidence. The stock’s sensitivity to commodity price fluctuations and global trade flows further complicates its near-term outlook.

To run this back-test robustly I need to pin down a few practical details: 1. Universe definition • Which exchange(s) or index universe should the “top-500 by volume” be drawn from? • Is there a readily available list you would like me to use (e.g., all U.S. listed equities, S&P 1500 constituents, etc.)? 2. Trading convention • Do we buy at the same day’s close and sell at the next day’s close (i.e., an overnight hold), or buy at next day’s open and sell at that day’s close (an intraday hold)? • Slippage and transaction costs – should we assume zero for this test, or apply a standard rate (e.g., 5 bps each side)? 3. Benchmark / risk-free rate • Any benchmark you would like the results compared against? • Risk-free rate assumption (use 3-month T-Bills, or ignore)? Once I have these details I can set up the data retrieval plan and run the back-test.