Tempus AI Gains 1.55% Despite 36.61% Volume Drop to $540M Ranks 223rd in Market Activity

On October 6, 2025, Tempus AI (TEM) closed with a 1.55% gain, despite a 36.61% decline in trading volume to $540 million, ranking 223rd in market activity. The stock's performance reflects ongoing investor interest in AI-driven biotechnology platforms amid evolving market dynamics.

Recent developments highlight Tempus' strategic positioning in the healthcare AI sector. The company has been refining its genomic data analytics tools to enhance precision medicine applications, a move that aligns with growing institutional demand for AI solutions in clinical decision-making. Analysts note that Tempus' ability to integrate real-time patient data with machine learning models remains a key differentiator in a competitive landscape.

Back-testing parameters for Tempus' trading strategy require precise definitions of market universes, portfolio construction rules, and execution protocols. Key considerations include selecting the "top-500 by daily dollar volume" from a defined market, rebalancing frequency, position sizing, and liquidity assumptions. Data constraints necessitate access to bulk OHLC price feeds and volume data for accurate replication of historical performance from January 3, 2022, to October 6, 2025.