Syncell and Thermo Fisher Collaborate on High-Resolution Spatial Proteomics Workflow

Syncell and Thermo Fisher have formed a strategic co-marketing agreement to advance high-resolution spatial proteomics. The collaboration integrates Syncell's Microscoop technology with Thermo Fisher's Orbitrap mass spectrometer series, enabling unbiased spatial proteomics with high subcellular resolution. The combined workflow unlocks comprehensive protein mapping and discovery across biological systems in various fields, including oncology, neuroscience, and drug discovery.

Title: Syncell and Thermo Fisher Collaborate to Advance High-Resolution Spatial Proteomics

Syncell Inc. and Thermo Fisher Scientific have announced a strategic co-marketing agreement aimed at revolutionizing high-resolution spatial proteomics. The collaboration integrates Syncell's proprietary Microscoop technology for spatial protein purification with Thermo Fisher's ultra-sensitive Orbitrap Astral mass spectrometer series, enabling unbiased spatial proteomics with high subcellular resolution [1].

The combined workflow integrates Syncell’s Microscoop Mint system, which performs real-time, microscopy-guided spatial protein purification, with the Orbitrap Astral mass spectrometer series. This integration delivers unmatched acquisition speed, proteome depth, and spatial resolution, allowing researchers to investigate the location and organization of proteins across tissues and cells without relying on predefined targets [2].

This collaboration marks a significant advancement over traditional antibody-based spatial methods, opening new possibilities for comprehensive protein mapping and discovery across various biological systems, including oncology, neuroscience, drug discovery, immunology, and cell biology [1].

"The integration of the Syncell Microscoop technology with the Astral Orbitrap mass spectrometer has transformed our capacity to interrogate biology," said Luisa Iruela-Arispe, PhD, chair of the Department of Cell and Developmental Biology at the Northwestern Medicine Feinberg School of Medicine. "By uniting the nanometer-scale spatial resolution of the Syncell Microscoop technology with the ultra-sensitive detection of the Astral mass spectrometer, we have achieved an analytical capability that pushes the boundaries of cell signaling, revealing spatial and chemical detail that has never before been accessible" [2].

The combined technologies unlock a hypothesis-free approach to subcellular proteome analysis in fresh and formalin-fixed, paraffin-embedded (FFPE) tissues as well as in cell culture samples. This innovation is expected to democratize access to high-resolution, unbiased spatial proteomics and set a new gold standard for proteomic discovery at the cellular and subcellular level [2].

Syncell, a commercial-stage life science company focused on subcellular protein purification and unbiased spatial proteomics analysis, has raised $40 million from investors to date. The company has commercialized its Microscoop technology, helping researchers accurately discover new protein components from targeted regions of interest [2].

This strategic partnership underscores the potential of combining innovative technologies to drive advancements in life science research and drug discovery. As the market for spatial proteomics continues to grow, this collaboration is poised to significantly impact various sectors, from pharmaceuticals to biotechnology.

References

[1] https://www.marketscreener.com/news/syncell-inc-announces-strategic-co-marketing-agreement-to-advance-high-resolution-spatial-proteomi-ce7c51d9dc81f222
[2] https://www.businesswire.com/news/home/20250814833588/en/Syncell-Announces-Strategic-Co-Marketing-Agreement-to-Advance-High-Resolution-Spatial-Proteomics