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ProKidney Corp. (NASDAQ:PROK) surged 5.7692% in pre-market trading on December 17, 2025, driven by a new Buy rating from H.C. Wainwright & Co. The firm set a $12.00 price target, signaling over 475% potential upside from its current level. This marks the first analyst coverage for the clinical-stage biotechnology company, which is developing REACT, a cell therapy targeting chronic kidney disease.
The positive momentum follows a strategic shift in analyst sentiment, with H.C. Wainwright’s Joseph Pantginis highlighting ProKidney’s proprietary platform for autologous cell therapy.

ProKidney’s pipeline remains centered on advancing REACT through clinical trials, aiming to slow disease progression using patient-derived renal cells. While broader market risks persist, the firm’s elevated target price reflects confidence in its long-term therapeutic value and unmet medical needs in kidney disease treatment.
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