Moderna's Stock Climbs 3.54% on FDA Vaccine Approval, Ranks 337th in $0.33 Billion Trading Volume Surge

On September 5, 2025, , , . The biotech stock ranked 337th in trading activity across the market.

Moderna recently secured U.S. approval for an updated mRNA-based COVID-19 vaccine targeting the LP.8.1 variant of SARS-CoV-2, signaling regulatory progress in its vaccine portfolio. The company also announced plans to expand into with a pan-tumor vaccine candidate, broadening its therapeutic focus beyond infectious diseases. However, insider transactions and market sentiment remain mixed, .

Healthcare sector dynamics have influenced Moderna’s performance, as broader market trends and political debates over vaccine mandates continue to shape investor perceptions. , though long-term challenges persist amid a volatile regulatory and competitive landscape.

To run this test rigorously I need to pin down a few details that are not yet explicit and make sure they fit within the capabilities of the back-testing engine we have available.

1. Universe

• Do you want to look at all U.S. listed common stocks, or a narrower universe (e.g., S&P 1500 constituents, Nasdaq + NYSE, etc.)?

• The engine we have today evaluates one ticker (or an index ticker) at a time; to replicate a 500-stock basket we would have to model the basket as an index or ETF. If a ready-made index/ETF that represents “most-actively‐traded-by-volume” is acceptable (for example the Bloomberg Most Active 500 index, ticker B500V), that will plug straight into the engine. Otherwise we would have to construct daily basket holdings outside the current tooling.

2. Weighting scheme

• Equal-weight each of the 500 names?

• Or dollar-volume-weight them?

3. Transaction assumptions

• “Hold for 1 day” – do we assume buy at the day’s close and sell at the next day’s close?

• Any trading-cost or slippage assumption you’d like me to include?

If using an existing index/ETF that tracks the “top-volume 500” concept is acceptable, we can proceed immediately. If you prefer a fully custom daily-rebalanced basket, we’d need to construct that signal set first (which our current tool set cannot automate in a single step), and I can outline the required data pipeline for you.

Let me know which route you prefer, and once I have that guidance I’ll set up the back-test parameters and run the analysis.