McKesson Shares Climb 0.74% Amid 32.76% Volume Surge, Rank 302nd Most Traded

McKesson (MCK) rose 0.74% on October 10, 2025, with a trading volume of $0.42 billion, marking a 32.76% increase from the previous day’s volume. The stock ranked 302nd in terms of trading activity among listed equities.

Recent developments suggest mixed market dynamics for the healthcare distribution giant. While no direct operational updates were disclosed, the surge in trading volume indicates heightened investor interest, potentially linked to broader sector trends or macroeconomic factors. Analysts noted that volume spikes often precede significant price movements, though no material news was reported to justify the intraday gains.

Excluding unrelated market commentary and third-party platform references, the core narrative remains focused on McKeon’s liquidity profile. The stock’s performance aligns with its historical pattern of volatility amid sector consolidation and regulatory scrutiny. However, the absence of earnings reports or strategic announcements during the period leaves the immediate catalyst for the volume increase unclear.

To run this back-test accurately, I’ll need a couple of details that aren’t fully specified yet:

1. Universe

• Do we limit the stock pool to a specific exchange or index (e.g., all U.S. listed common stocks, S&P 500 constituents, etc.)?

• Or do you already have a daily list of the “top-500-by-volume” tickers that I should use?

2. Weighting & transaction assumptions

• Equal-weight each day’s 500 names, or weight them by something else (e.g., proportional to volume)?

• Ignore transaction costs / slippage, or apply a standard assumption?

Once I have this information, I can pull the required data, generate the daily trade lists, and run the 1-day-hold back-test from 2022-01-01 through today.