Madrigal Surges 8.59 on 290th-Ranked $410M Volume as Patent Extensions and $212M Rezdiffra Sales Drive Momentum

Madrigal Pharmaceuticals (MDGL) surged 8.59% on August 5, 2025, with a trading volume of $410 million, ranking 290th in market activity. The stock’s rally followed a series of strategic and operational updates, including extended intellectual property protection, expanded therapeutic pipeline, and financial strengthening.

The company reported $212.8 million in Rezdiffra sales for Q2 2025, driven by robust demand for its MASH treatment. A newly issued U.S. patent, covering Rezdiffra’s commercial dosing regimen, now extends protection until 2045, reinforcing market exclusivity. This development addresses long-term competitive risks and aligns with the company’s focus on scaling Rezdiffra across fibrosis stages and geographies.

In July, Madrigal secured a $500 million senior secured credit facility from Blue Owl Capital, comprising an initial $350 million term loan and a $150 million delayed draw. The non-dilutive financing supports pipeline advancements, including a licensing agreement for SYH2086, an oral GLP-1 candidate to complement Rezdiffra. The company also presented two-year F4c MASH cirrhosis data at EASL, highlighting sustained efficacy in liver stiffness and fibrosis markers.

A positive CHMP opinion for Rezdiffra in Europe positions Madrigal for potential EU market entry by August 2025. The regulatory nod, combined with existing inclusion in European clinical guidelines, underscores the therapy’s growing international relevance. Additionally, the appointment of Dan Brennan to the board, a former Boston Scientific CFO, signals strategic governance enhancements.

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