Humana Gains 1.88% Amid 50.45% Volume Drop to $570M 200th in Market Activity

Humana (HUM) closed on September 11, 2025, , , ranking it 200th among active equities. The stock’s performance followed a detailed review of back-testing parameters for a large-cap portfolio strategy. Key uncertainties remain in defining the exchange universe, weighting methodology, and execution rules for a robust analysis of volume-driven trading dynamics.

Back-test configurations require clarification on critical variables, including whether to limit the stock pool to NYSE, NASDAQ, and AMEX-listed equities or focus on S&P 500 constituents. . Execution timing, transaction cost assumptions, and inclusion of delisted tickers further complicate the modeling process. These factors directly influence the accuracy of portfolio-level return and risk metrics.

To proceed, the back-test will construct a “virtual index” aggregating top-500-by-volume positions, with profit and loss data processed as a composite series. However, execution parameters, including price points (close-to-close, open-to-open, etc.) and slippage adjustments (e.g., , must be confirmed before data retrieval. The methodology aims to isolate volume-based alpha generation while maintaining statistical integrity in the analysis.