Gilead's GILD Rises 1.26% on $720M Volume Ranking 156th as IRAK4 Degrader Collaboration Nears Clinical Trials

On September 17, 2025, , ranking 156th in the day’s market activity. The stock’s performance coincided with developments from its collaboration with Nurix Therapeutics, which presented preclinical data for GS-6791, an under joint development. The compound demonstrated sustained IRAK4 degradation and reduced inflammatory responses in skin models, supporting its advancement to clinical trials.

Gilead exercised its licensing option for GS-6791 in March 2023 and secured FDA approval for its Investigational New Drug application in April 2025. A Phase 1 trial evaluating safety and pharmacodynamics in healthy volunteers is ongoing. Nurix, under the 2019 collaboration, . The partnership also includes a preclinical and other pipeline candidates.

Analysts have highlighted the strategic value of Gilead’s protein degradation platform, which aligns with its focus on expanding therapeutic options for inflammatory diseases. The collaboration’s financial structure and progress underscore Gilead’s long-term R&D investment, though Nurix’s liquidity position and cash burn rate remain critical for pipeline sustainability.

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