Caribou Biosciences 2025 Q3 Earnings Narrowed Losses and Strong Clinical Data

Caribou Biosciences (CRBU) reported Q3 2025 earnings on Nov 12, 2025, with a narrowed net loss and positive clinical updates. The company exceeded adjusted EPS estimates but fell short of revenue projections. Management emphasized progress in pivotal trial planning and cash runway sustainability.

Revenue

Caribou’s total revenue rose 8.6% year-over-year to $2.20 million in Q3 2025, driven by licensing and collaboration agreements. Pfizer-related revenue contributed $622,000, while other licensees added $1.58 million, culminating in total licensing and collaboration revenue of $2.20 million. This segment growth reflects ongoing partnerships and commercialization efforts.

Earnings/Net Income

The company narrowed its loss per share to $0.30 in Q3 2025, a 21.1% improvement from $0.38 in the prior-year period. Net loss also decreased by 20.6% to $-27.55 million, compared to $-34.68 million in 2024 Q3. Despite these improvements, Caribou has sustained losses for six consecutive years, underscoring persistent financial challenges. The reduced losses signal operational efficiency gains.

Price Action

Post-earnings, CRBU shares saw mixed performance. The stock edged up 0.89% on the latest trading day, climbed 3.20% for the week, but declined 5.04% month-to-date. Analysts will monitor how these trends align with broader market sentiment and clinical milestones.

Post-Earnings Price Action Review

Following the earnings report, Caribou’s stock exhibited modest short-term gains, buoyed by narrowed losses and positive clinical data. However, the revenue miss and continued net losses tempered investor enthusiasm. The 0.89% daily rise and 3.20% weekly gain suggest cautious optimism, though the 5.04% monthly decline highlights underlying volatility. Market participants remain focused on the company’s ability to secure funding for pivotal trials and deliver on its allogeneic CAR-T pipeline.

CEO Commentary

Rachel Haurwitz, PhD, highlighted robust clinical data from the ANTLER and CaMMouflage phase 1 trials, emphasizing vispa-cel and CB-011’s potential as best-in-class allogeneic CAR-T therapies. She underscored the importance of optimizing donor age and HLA matching to enhance outcomes and align with FDA guidance for pivotal trials.

Guidance

Caribou anticipates refining the pivotal phase 3 trial design for vispa-cel in 2L LBCL through 2025 FDA discussions. CB-011 dose expansion is expected by year-end, with data and follow-up results in 2026. The company projects current cash reserves of $159.2 million to fund operations through mid-2027 and is exploring funding options for the vispa-cel pivotal trial.

Additional News

Caribou’s Medical - Biomedical and Genetics industry, ranked in the top 34% by Zacks, faces mixed outlooks. While the sector outperforms 50% of Zacks industries, Caribou’s Zacks Rank #4 (Sell) reflects unfavorable estimate revisions. Dare Bioscience (DARE), a peer in the same industry, is set to report Q3 results on Nov 13, with a projected $0.33 loss per share, unchanged from prior estimates. Analysts will watch how industry trends and capital-raising efforts shape Caribou’s near-term trajectory.

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