Aptevo Therapeutics Shares Soar 40.43% on 1030% Trading Volume Surge Ranks 410th in Market Activity

On September 18, 2025, , . The stock ranked 410th in trading activity across the market, .

Recent developments suggest heightened investor interest in Aptevo, driven by strategic initiatives and operational updates. The company has been focusing on advancing its pipeline in oncology and rare diseases, with several key programs entering critical phases. Analysts have highlighted the potential for near-term catalysts, including data readouts and regulatory updates, which could further influence market sentiment.

To make sure I set up the test exactly the way you intend, could you please confirm a few details? Market universe: Should the “top-500” selection be drawn from all U.S. common stocks (NYSE + NASDAQ), or a different universe (e.g., only S&P 500 constituents, only a specific exchange, another country, etc.)? , or weight them by something else (e.g., ? . , . ? , , , ? Once I have these details, I can lay out the exact data-collection plan and run the back-test.