

The significant drop in Iovance Biotherapeutics Inc (IOVA) stock price today, followed by a substantial pre-market increase, can be attributed to several factors:12
1. Overall Market Trend: Despite a positive overall market trend, as indicated by the S&P 500 Index's 2.07% increase, IOVA's performance diverged. This could signal specific issues affecting IOVA or investor sentiment about the stock.
2. Pre-market Volatility: The pre-market saw substantial volatility, with IOVA's stock rising by 7.09%. This could be due to lower trading volume and speculative activity, influencing the stock's movement.13
3. Bullish Sentiment: IOVA received a bullish sentiment score from the InvestorsObserver Stock Sentiment Indicator. This indicates positive short-term technical analysis, potentially attracting investors.
4. FDA Approval: The FDA's accelerated approval of Amtagvi (lefileucel) as a treatment for advanced melanoma likely boosted investor confidence. This news, coupled with the holiday-delayed market reaction, could explain the significant pre-market surge.
5. Earnings Expectations: The anticipation of upcoming earnings, with IOVA's stock already having risen by over 120%, could be driving investor optimism. Higher earnings expectations often lead to increased stock prices.
In summary, IOVA's low performance today, followed by a notable pre-market increase, can be attributed to a combination of overall market trends, pre-market volatility, bullish sentiment, FDA approval news, and expectations for upcoming earnings. These factors collectively explain the stock's movement and investor behavior.
