When will they have a hsv vaccine? any hope?

**GSK's HSV Vaccine Development Status**:

1. **Discontinuation of GSK3943104**: GSK recently announced the discontinuation of its herpes simplex virus (HSV) therapeutic vaccine candidate, GSK3943104, following the failure of a Phase I/II clinical trial to meet its primary efficacy goals.
2. **Lack of Efficacy**: The vaccine was designed to reduce lesions in patients with recurrent genital herpes, a high unmet medical need. Although deemed safe, its lack of efficacy led to GSK's decision not to advance the vaccine into Phase III trials.
3. **Significance of Failure**: This effectively ends GSK's ambition to bring the first HSV vaccine to market, highlighting the significant challenges inherent in developing a vaccine against genital herpes.

**Implications and Future Directions**:

1. **Unmet Medical Need**: HSV remains a highly prevalent infection worldwide, with millions affected by either HSV-1 or HSV-2. The failure of GSK3943104 underscores the urgent need for effective therapeutic and prophylactic solutions.
2. **Ongoing Research**: Other companies, including Moderna and BioNTech, are actively pursuing HSV vaccine candidates. While no vaccines have been approved for use in humans thus far, ongoing research holds hope for future success.
3. **Alternative Approaches**: The failure of GSK3943104 does not preclude the development of an HSV vaccine. Other therapeutic approaches, such as those being explored by Rational Vaccines, are also in progress.

In summary, while GSK's HSV vaccine candidate has recently failed to meet efficacy goals, the broader HSV vaccine landscape continues to evolve, with ongoing research and development by various pharmaceutical companies. The unmet medical need for an HSV vaccine remains high, offering hope for future successes in this area.