In the context of genetics and oncology, "wild type" refers to the normal, unmutated form of a gene. It indicates that the gene is functioning as it should, without any mutations or alterations that could lead to disease or abnormal function.
For example, in the case of the estrogen receptor 1 (ESR1) gene, wild-type ESR1 means that the gene has not been mutated and is functioning normally, allowing the estrogen receptor to respond appropriately to estrogen hormones. In contrast, ESR1-mutant tumors have acquired mutations in the ESR1 gene, which can lead to resistance to endocrine therapies and a more aggressive tumor phenotype.
Wild-type genes are typically associated with normal cellular function and are not associated with disease. However, in the context of cancer research, the term "wild type" is often used to refer to the absence of specific mutations that can drive tumorigenesis or confer resistance to therapy.
In summary, "wild type" in genetics and oncology refers to the normal, unmutated form of a gene, which is functioning as expected without any alterations that could lead to disease or abnormal function.
7/1/2025 05:28pm
