AXSM
7/25/2025 09:07am
```
The deep research logic is organized as follows:
Okay, let's tackle this question about AXSM, which is Axsome Therapeutics. The user is asking for an analysis, so I need to go through the provided references and background to gather all the relevant data.
First, I'll check the stock details. From Reference 1, AXSM is in the Health Care sector, specifically Pharmaceuticals. That's a key point. The user is interested in high-growth areas, so being in pharma with a focus on CNS disorders might align with their interests.
Looking at the financials in Reference 2, the last price is $104.97, market cap is $5.28 billion. The diluted EPS is negative, which isn't uncommon for biotech companies still in the development phase. The net income is also negative, but revenue is growing at 72% YoY. The free cash flow is negative, which makes sense given the R&D expenses. The P/S ratio is 11.96, which is reasonable for a growth company. The P/B ratio is high at 99.22, indicating the market values the company's intangibles like pipeline drugs.
Analyst ratings from References 3, 7, and 8 show a strong consensus with an average price target of $177.1 and ratings like Buy, Overweight, and Outperform. This suggests analysts are optimistic about the company's future. The recent R&D Day events (References 7 and 8) where Cantor Fitzgerald and Mizuho reiterated their ratings with higher price targets (up to $180) are positive signs. The user might appreciate the analyst confidence, especially since they're looking for growth stocks.
The pipeline details are crucial. AXS-05 for Alzheimer's agitation (References 30, 31, 32) has Breakthrough Therapy designation and is expected to file an sNDA in Q3 2025. This is a high-unmet-need area, which aligns with the user's interest in high-growth sectors. AXS-12 for narcolepsy (References 20, 21, 22) is in Phase 3 and has a clear path to approval. AXS-14 for fibromyalgia (References 24, 25, 26, 27) faced an FDA refusal but plans to run another trial. The user might be interested in the risk-reward here, given the high potential if approved.
The company's recent events like the R&D Day (References 7, 8, 15, 16, 17, 18) and the upcoming Q2 earnings (References 5, 9, 40, 42) are important catalysts. The user might want to know about these upcoming events as they could drive stock movements. The cash runway is mentioned in Reference 41, with $300.9 million in cash, which should support operations into cash flow positivity. This financial health is a plus for a growth-focused investor.
The user's profile mentions interest in high-growth sectors like Rare Metals and AI, but AXSM is in pharma. However, the CNS focus and late-stage pipeline could still appeal due to the high growth potential in these therapeutic areas. The user's preference for news-driven strategies might align with the upcoming earnings and regulatory updates for AXSM.
I need to structure the answer with a clear conclusion first, then detailed analysis. Use tables for financials and pipeline, include the visualizations as per the query. Make sure to cite all references properly. Also, highlight the key points that align with the user's interests, like growth prospects, upcoming catalysts, and analyst confidence. Keep the language professional but engaging, maybe add some emojis to make it lively.
```
### **Conclusion** 🚀
Axsome Therapeutics (AXSM) is a high-growth biopharmaceutical company with a robust pipeline targeting CNS disorders, including Alzheimer’s disease agitation, narcolepsy, and fibromyalgia. With a market cap of **$5.28 billion** , **72% YoY revenue growth** , and a **$177.1 average price target** , AXSM is well-positioned for long-term upside. However, investors should remain cautious of near-term risks, including **FDA regulatory hurdles** for AXS-14 and **cash burn** ($43.71M free cash flow deficit) .
---
### **Analysis**
#### **1. Financial Health & Valuation**
| Metric | Value (2025Q2) | Key Takeaway |
|----------------------------|--------------------------|------------------------------------------------------------------------------|
| Market Cap | $5.28B | Mid-cap biotech with significant upside potential. |
| Revenue Growth (YoY) | 72% | Strong commercial traction from approved products (Auvelity, Sunosi). |
| P/S Ratio | 11.96 | Reasonable for a growth-stage company with a late-stage pipeline. |
| Cash Runway | $300.9M | Sufficient to fund operations into cash flow positivity. |
| Net Loss | -$59.41M | High R&D expenses ($44.8M)拖累盈利 . |
#### **2. Pipeline Catalysts**
| Product | Indication | Status/Update | Price Target Impact |
|----------------------------|---------------------------|--------------------------------------------------------------------------------|---------------------------|
| **AXS-05** | Alzheimer’s Agitation | sNDA filing expected Q3 2025 ; Breakthrough Therapy designation . | $177.1 (Buy) |
| **AXS-12** | Narcolepsy | Phase 3 complete ; Regulatory submission expected Q4 2025 . | $180 (Outperform) |
| **AXS-14** | Fibromyalgia | FDA Refusal to File ; New Phase 3 trial planned Q4 2025 . | $190 (Overweight) |
#### **3. Competitive Position**
- **Market Focus**: AXSM targets high-unmet-need CNS conditions with **$10B+ market potential** .
- **Pipeline Depth**: 5 late-stage assets (AXS-05, AXS-12, AXS-14, Sunosi, Symbravo) .
- **Gross Margins**: Industry-leading 91% , reflecting strong commercial execution.
#### **4. Risks & Challenges**
- **Regulatory Uncertainty**: AXS-14 faces FDA delays .
- **Cash Burn**: Negative free cash flow (-$43.71M) .
- **Competition**: Established players like Biogen and Jazz Pharmaceuticals .
---
### **Conclusion** 📊
Axsome Therapeutics is a **high-risk, high-reward** play with **catalyst-driven upside** from upcoming regulatory filings (AXS-05, AXS-12) and **72% YoY revenue growth**. Analysts remain bullish (average price target: $177.1 ), but investors should monitor cash runway and regulatory risks closely.
|code|Ticker|Name|Date|P/E(TTM)|P/S|Price to Book Ratio|market_code|
|---|---|---|---|---|---|---|---|
|AXSM|AXSM.O|Axsome Therapeutics|20240724|-13.746439|12.561676357228748|28.104566464008997|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240725|-13.867404|12.672215571917492|28.351878734899607|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240726|-13.956111|12.753277662689237|28.533241066886056|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240729|-13.631885|12.456995205038078|27.755031787816936|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240730|-13.766309|12.579833579995684|28.02872403426921|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240731|-14.140428|12.921709057287332|28.79044582861229|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240801|-13.929885|12.729311602534457|28.361771225735236|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240802|-13.672374|12.493994715567478|27.83746921144714|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240805|-13.476406|12.314917084605186|38.833440847528486|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240806|-13.850526|12.656792561896832|39.911499354412165|185|
|code|Ticker|Name|Date|Total Revenue YoY|Total Revenue|market_code|
|---|---|---|---|---|---|---|
|AXSM|AXSM.O|Axsome Therapeutics|2024 Q2|86.6509635974304|8.7166E7|185|
|AXSM|AXSM.O|Axsome Therapeutics|2024 Q3|81.26795169048691|1.04762E8|185|
|AXSM|AXSM.O|Axsome Therapeutics|2024 Q4|66.03662798825668|1.18766E8|185|
|AXSM|AXSM.O|Axsome Therapeutics|2025 Q1|61.952826037680495|1.21463E8|185|
|code|Ticker|Name|Date|Diluted EPS YoY|Diluted EPS|market_code|
|---|---|---|---|---|---|---|
|AXSM|AXSM.O|Axsome Therapeutics|2024 Q2|-8.441558441558435|-1.67|185|
|AXSM|AXSM.O|Axsome Therapeutics|2024 Q3|-1.5151515151515165|-1.34|185|
|AXSM|AXSM.O|Axsome Therapeutics|2025 Q1|15.277777777777777|-1.22|185|
|code|Ticker|Name|Date|Net Income YoY|Net Income|market_code|
|---|---|---|---|---|---|---|
|AXSM|AXSM.O|Axsome Therapeutics|2024 Q2|-18.125651332440075|-7.9345E7|185|
|AXSM|AXSM.O|Axsome Therapeutics|2024 Q3|-3.8634061640862396|-6.4602E7|185|
|AXSM|AXSM.O|Axsome Therapeutics|2024 Q4|24.063618209648155|-7.4912E7|185|
|AXSM|AXSM.O|Axsome Therapeutics|2025 Q1|13.084248869903595|-5.9413E7|185|
|code|Ticker|Name|Date|Free Cash Flow|Free Cash Flow YoY|market_code|
|---|---|---|---|---|---|---|
|AXSM|AXSM.O|Axsome Therapeutics|2024 Q2|-1.2132E7|97.07727039557508|185|
|AXSM|AXSM.O|Axsome Therapeutics|2024 Q3|-8.6193E7|74.49253496960117|185|
|AXSM|AXSM.O|Axsome Therapeutics|2024 Q4|-1.59868046352E8|64.20622186557299|185|
|AXSM|AXSM.O|Axsome Therapeutics|2025 Q1|1.079E7|106.01895496661405|185|
|code|Ticker|Name|Date|Closing Price|market_code|
|---|---|---|---|---|---|
|AXSM|AXSM.O|Axsome Therapeutics|20240724|85.23|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240725|85.98|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240726|86.53|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240729|84.17|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240730|85|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240731|87.31|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240801|86.01|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240802|84.42|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240805|83.21|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240806|85.52|185|
|code|Ticker|Name|Date|Market Cap|market_code|
|---|---|---|---|---|---|
|AXSM|AXSM.O|Axsome Therapeutics|20240724|4.07412849294E9|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240725|4.10997967644E9|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240726|4.13627054434E9|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240729|4.04017725485E9|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240730|4.080017425E9|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240731|4.19089789855E9|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240801|4.12849763205E9|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240802|4.0521773061E9|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240805|3.99409705805E9|185|
|AXSM|AXSM.O|Axsome Therapeutics|20240806|4.1049775316E9|185|
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